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《Journal of Clinical and Pathological Research》 2015-03
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Expression of FHL1 in human pancreatic cancer tissue and its correlation with the invasion and metastasis of pancreatic cancer

LIU Zhe;XU Yuanhong;LONG Jin;GE Chunlin;BI Shulong;DU Ruixia;JIANG Hongjun;Department of Pancreatic Surgery, the First Hospital of China Medical University;Department of Otorhinolaryngology,Fengtian Hospital of Shenyang Medical University;Department of Radiology, Fengtian Hospital of Shenyang Medical University;  
Objective: To study the expression of four and a half LIM domains 1(FHL1) in human pancreatic carcinoma tissue and its correlation with the clinicopathological characteristics of pancreatic cancer. Methods: The expression of FHL1 protein in 62 pancreatic cancer tissues and the adjacent normal pancreatic cancer tissue were determined using western blots. The association between the expression of FHL1 protein and the prognosis of patients were analyzed by Log-rank test. Results: Expression of FHL1 protein in pancreatic carcinoma tissue was significantly lower than that in the adjacent normal tissue(P0.01). The expression of FHL1 was closely associated with clinical stage, degrees of dif erentiation, TNM stages, lymph node metastasis and distant metastasis(P0.05). The survival time of the patients with low FHL1 expression signii cantly shortened(P0.01). Conclusion: The novel expression of FHL1 may be related to the incidence, progression, invasiveness, and metastatic potential of pancreatic cancer.
【Fund】: 辽宁省教育厅科学研究一般项目(L2014299);; 辽宁省科学技术计划项目(2011404013-4)~~
【CateGory Index】: R735.9
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【References】
Chinese Journal Full-text Database 1 Hits
1 Wang Hui;Wei Juan;Liu Tong;Wang Fangyu;Department of Gastroenterology,Nanjing General Hospital of Nanjing Military Region,PLA;;Expression of FHL1 and the significance in pancreatic fibrosis of chronic pancreatitis[J];中华胰腺病杂志;2016-06
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 Chen Haoyu;Shen Xiangguo;Li Zhaoshen;Xu Can;Department of Gastroenterology,Changhai Hospital,Second Military Medical University;;IL-18 and CX3CL1 expression and function in the fibrosis of chronic pancreatitis rat[J];中华胰腺病杂志;2016-02
2 LIU Zhe;XU Yuanhong;LONG Jin;GE Chunlin;BI Shulong;DU Ruixia;JIANG Hongjun;Department of Pancreatic Surgery, the First Hospital of China Medical University;Department of Otorhinolaryngology,Fengtian Hospital of Shenyang Medical University;Department of Radiology, Fengtian Hospital of Shenyang Medical University;;Expression of FHL1 in human pancreatic cancer tissue and its correlation with the invasion and metastasis of pancreatic cancer[J];临床与病理杂志;2015-03
3 Natalia JURA1,2, Herbert ARCHER1,2, Dafna BAR-SAGI1,* 1Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA. 2Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY 11794-5222, USA.;Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between[J];Cell Research;2005-01
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