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《Journal of Clinical and Pathological Research》 2015-03
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NLRP3 inflammasome role in the occurrence and development of atherosclerosis

GAN Xianghai;LV Zhan;Department of Cardiology, Affiliated Hospital of North Sichuan Medical College;  
The NLRP3 inflammasome is a protein complex that includes an intracellular sensor(mainly a NOD-like receptor), the precursor procaspase-1 and the adaptor ASC. Initially the inflammasome was described as a complex which influences infection and inflammation. Inflammasome activation leads to the maturation of caspase-1 and the process of its substrates, interleukin-1β(IL-1β) and interleukin-18(IL-18), which leads to inl ammatory response. Moreover, another feature of inl ammation is that the process of activating inl ammasome has a significant effect on aerobic glycolysis("Warburg effect"). Subsequent evidences have suggested that inl ammasome activation af ects many metabolic disorders, including atherosclerosis(AS), type 2 diabetes, gout and obesity. We will discuss the relationship among AS, inl ammation and NLRP3 inl ammasome activation, and how the Warburg effect may link to inl ammation and inl ammasome activation in this review.
【CateGory Index】: R543.5
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