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《Journal of Clinical and Pathological Research》 2015-07
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Effect of percutaneous coronary intervention on plasma MMP-9, CRP, IL-18 and CTnI in patients with unstable angina pectoris

HU Zhangle;WANG Xiaochen;XU Banglong;SHENG Jianlong;ZHANG Yanmei;Department of Cardiology, the Second Affiliated Hospital of Anhui Medical University;  
Objective: To explore the effect of percutaneous coronary intervention(PCI) on plasma activity of matrix metalloproteinase-9(MMP-9), C-reactive protein(CRP), interleukin 18(IL-18) and cardiac troponin I(CTnI) in patients with unstable angina pectoris. Methods: A total of 116 patients with unstable angina pectoris were randomized to non-PCI(NPCI) or PCI treatment. Baseline characteristics of both groups were recorded and the plasma samples were collected on admission and 24, 72 h, 2 weeks after the procedure(coronary angiography for NPCI group, percutaneous coronary intervention for PCI group) respectively in all patients to measure plasma concentration of MMP-9, CRP, IL-18 and CTnI. Results: There was no difference in clinical characteristics and plasma MMP-9, CRP, IL-18 and CTnI levels on admission and 2 weeks after the procedure between both groups(all P0.05). After the procedure, for NPCI group, there was no difference in MMP-9, CRP, IL-18 and CTnI concentrations amongst the first three timings(all P0.05). However, their levels dropped at 2 weeks(all P0.01). After the procedure, for PCI group, MMP-9, CRP, IL-18 and CTnI concentrations markedly increased at 24 h and further elevated at 72 h and then significantly dropped at 2 weeks(all P0.01). NPCI group illustrated significantly lower plasma MMP-9, CRP, IL-18 and CTnI levels than PCI group at 24 and 72 h after the procedure(all P0.01). Conclusion: PCI procedure probably induces plaque vulnerability and insult myocardium in a short time.
【CateGory Index】: R541.4
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