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《Journal of Clinical and Pathological Research》 2015-07
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Overview of miRNA detection methods

LI Wanqin;HE Rongfang;GAN Runliang;Nanhua University;Department of pathology, Nanhua University;Tumor Institute of Nanhua University;  
Micrornas are a kind of mature from 19 to 22 nucleotides of small non-coding RNA molecules(nc RNAs). They have now been found in all animals and plants studied to date, representing about 4% of the genomes. miRNAs has been shown to play a role in the normal growth and development of life as well as many human diseases such as cancer, cardiovascular disease. The exact role of each miRNA in each specific organ, tissue or cell is yet to be investigated. The small size of the miRNAs, however, has been a limiting factor to detect it. Therefore, development of sensitive detection methods for miRNAs, both at the tissue and the cellular level, has been an important milestone in miRNA biology. This article concluded miRNA detection methods, focuses on the methods which are used for pathological specimens and some effective detection methods, to provide a further technical support for miRNAs detection.
【Fund】: 国家自然科学基金(81372134)~~
【CateGory Index】: R440
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