EFFECTS OF RESERPINE ON AURICLE OF GUINEA PIG
Zhao Dongke, et al (Department of Pharmacology)
Effects of reserpine on the physiologic properties of myocardium were studied in the auricle of quinea pig. Reserpine (10 μM) decreased the contractive force of the left auricle to 57 ±15% (P0.01) and the frequency of the right auricle from 147±10 beats per minute to 120 ±20 beats per minute (P0.01). It also decreased the epinephrine-induced automaticity and prolonged the functional refractory period from 183±14ms to 206±7 ms, while It did not change the duration-intensity curve (P0.05) in the left auricle of guinea pig, Reserpine shifted the dose-response curve of epinephrine positive frequency non-parallelly to the right with decrease of its maximum effect. It also possessed antagonistic effect for calcium positive frequency response. The results obtained indicate that reserpine might possesse calcium antagonistic effect.