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《Journal of Xi'an Jiaotong University(Medical Sciences)》 1992-01
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PROTECTION OF ADRIAMYCIN-INDUCED SUBACUTE CARDIOMYOPATHY IN MOUSE BY SELENIUM PRETREATMENT

Cheng Xing, Xu Guang-Lu, Xue Wenlan, et al (Research Laboratory of Keshan Disease)  
The protective effect of selenium (So) on the subacute cardiomyopathy was investigated in the mouse given a single dose of adriamycin (ADR 17. 5mg/kg ip). Se pretreatment (80μg/kg×10 ip) produced protection against the ADR-induced early myocardial damage associated with increased permcability of cell membranes as evidenced by apparent D- PAS (diastase- periodic acid-Schiff) staining material noted in the sarcolemma. The protective effect of Se could be partially explained as the detoxication of lipid peroxides via the action of enhanced cardiac Se-glutathione peroxidase.
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Cheng Xin & Xu Guanglu ( Xian Medical College, Xian );EFFECT OF ADRIAMYCIN ON HEART PEROXIDATION IN MICE[J];Chinese Pharmacological Bulletin;1989-04
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