A COMPARISON STUDY ON THE EFFECT OF OUABAIN AND DIGOXIN ON BLOOD PRESSURE OF RATS
Wang Hao, Lu Zhuoren(Da partment of Cardiovascular Internal Medicine, First Affiliated Hospital)
We administered ouabain to normotensive rats to observe its effect on blood pressure and compare with that of digoxin. The resultsshowed that ouabain, with small dose chronically,produced hypertension significantly, and digoxin didnot. It Droved indirectly that endogenous diuitalislike factor was ouabain, not digoxin, and it was oneof the causes of hypertension, but not secondary effect on hypertension. Also, we supplied a new model for the research of ouabain and hypertension:ouabain-hypertension rats in this study.
【CateGory Index】： R972.1