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《Journal of Xi'an Medical University(Chinese)》 2003-01
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Expression of and correlation between the vascular endothelial growth factor and transforming growth factor beta in patients with non-small cell lung cancer

Wei Xiaohong, Du Fenglan, Wang Hongyan, Lu Wanling (Department of Pulmonology Medicine, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China)  
Objective To investigate the expression of vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGFβ) and the correlation between them in patients with non-small cell lung cancer.Methods We examined the expression of VEGF protein and TGFβ 1 protein in surgical specimens of 50 patients with NSCLC by SP immunohistochemistry stain method. Results VEGF-positive rate was 66.00%, and VEGF was stained mainly in the cytoplasm of tumor cells of NSCLC. The positive expression rate of VEGF in stage Ⅱ and that in stage Ⅲ were significantly higher than that in stage Ⅰ (P0.05). Compared with the patients without lymph node metastasis, the positive expression of VEGF was significantly higher in the patients with lymph node metastasis (P0.05). No significant association was found between the VEGF expression and the histological types (P0.05). Similar to VEGF expression, positive expression rate of TGFβ 1 in stage Ⅱ and stage Ⅲ were significantly higher than that in stage Ⅰ (P0.05), and the positive expression of TGFβ 1 was significantly higher in the patients with lymph node metastasis than that without lymph node metastasis(P0.05). No significant association was found between the TGFβ 1 expression and the characteristics of the histological types (P0.05) of patients in NSCLC. The significant differences of positive expressions of VEGF and TGFβ 1 between carcinomatous and para-carcinomatous specimens were found. Of the 33 specimens with VEGF expression, the case of single VEGF expression (9/33) was evidently less than that of simultaneous expression of VEGF and TGFβ 1 (24/33). The same finding presented in case of the single TGFβ 1 expression (6/30) compared with that of the simultaneous expression of TGFβ 1 and VEGF (24/30). A positive correlation of VEGF expression and TGFβ 1 expression was found (r=0.362, P0.01). Conclusions The cooperation of VEGF and TGFβ 1 highly promotes the progression and lymph node metastasis of NSCLC partly because of the positive regulation of TGFβ 1 to VEGF. Further study on expression characteristics and regulating mechanisms of VEGF and TGFβ 1 may provide the theoretical basis for anti-tumor gene therapy in NSCLC.
【CateGory Index】: R734.2
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