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《Journal of Xi'an Medical University(Chinese)》 2003-01
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Study on the cytotoxic T lymphocytes of mice treated with leukemia vaccine

Zhao Wanhong, Zhang Wanggang, He Aili, Wang Yili, Gen Yipin, Tian Wei, Song Changsuo (Department of Hematology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China)  
Objective To study the cytotoxicity of cytotoxic T lymphocytes (CTL) derived from C 57BL/6 mice treated with the leukemia vaccine prepared by us. Methods We established leukemia burden mice and prepared three types of leukemia vaccine, which were administered on the mice respectively. The MTT colorimetric method was adopted 2 and 4 weeks later to measure the cytotoxicity of CTL derived from the mice which accepted immunotherapy or prevention. Then we compared it with that of control group. Results ① With the growth of leukemia cells in the mice, the cytotoxicity of CTL was severely depressed. ② The tumor vaccine prepared from inactivated tumor cells, IFA and cytokines (rGM-CSF, rIL-2 and rIL-6) promoted the cellular immunity of tumor burden mice more efficiently than the tumor vaccine made from either inactivated tumor cells, IFA or inactive tumor cells themselves alone. Conclusion The tumor vaccine prepared with inactive tumor cells, IFA and cytokines (rGM-CSF, rIL-2 and rIL-6) can activate the specific cellular immunity. Therefore, the tumor vaccine provides a promising future in the active specific immunotherapy against hematopoietic tumors.
【Fund】: 陕西省卫生厅重点科研基金 (No .2 0 0 0 Z0 1);; 西安交通大学第二医院科研基金 ( 2 0 0 0KG 4)
【CateGory Index】: R733.7
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