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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2005-01
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Mechanism of inhibitory effects of atropine and anisodamine on contractions of rabbit thoracic aorta

Liu Shuqin, Zang Weijin, Li Zengli, Sun Qiang, Yu Xiaojiang (Department of Pharmacology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China)  
Objective To investigate the vasodilative mechanisms of atropine and anisodamine (Ani). Methods Rabbit isolated aortic ring tension recording method was used. Results After 10 minutes of atropine (1, 3μmol/L) or Ani (1, 3μmol/L) pretreatment, the contractive responses of the endothelium-intact aorta to KCl (60, 30 and 20mmol/L) remained unchanged (P0.05, respectively), but those to noradrenaline (NA: 0.01μmol/L), histamine (His: 3μmol/L), and 5-hydroxytryptamine (5-HT: 0.1μmol/L), significantly reduced (P 0.01, respectively). Under Ani pretreatment, compared with atropine pretreatment, the NA-induced contractions were significantly weaker (P0.01, respectively), the His-induced contractions were significantly more powerful (P0.01 or 0.05), and the 5-HT-induced contractions and the Ani-induced contractions were comparative (P0.05, respectively). Under atropine or Ani pretreatment, the NA-, His- and 5-HT-elicited contractions in endothelium-denuded aorta were similar to those in endothelium-intact aorta. Conclusion Atropine and Ani can inhibit receptors-mediated constrictions of rabbit aortic vascular smooth muscle cells; the actions are endothelia independent.
【Fund】: 西安交通大学自然科学基金资助.
【CateGory Index】: R96
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