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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2005-01
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Genetic polymorphisms of interleukin-10 promoter region in patients with chronic HCV infection

Zeng Juntao, Liu Zhengwen, Han Qunying, Zhang Ni (Department of Infectious Diseases, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China)  
Objective To investigate the correlation between gene polymorphisms in IL-10 promoter region and the susceptibility and clinical phenotypes of HCV infection. Methods Two groups of subjects were studied. Group 1 included 85 treatment naive patients with chronic HCV infection, and group 2 included 75 healthy blood donors. Genotyping of IL-10 promoter-592 was performed by PCR-RFLP. Results No significant difference was found in IL-10 promoter-592 genotypes between the healthy individuals and HCV-infected patients. However, IL-10 promoter-592 genetype A/A appeared more frequently in patients with ALT≥80U/L than in those with ALT80U/L group (P0.01). Conclusion Genotype A/A appears more frequently in ALT≥80U/L patient group than in ALT80U/L group, suggesting that genetic polymorphisms of interleukin-10 may be related to inflammatory reaction in the liver of the patients with chronic HCV infection.
【Fund】: 陕西省科技攻关项目(2000K14-G16)
【CateGory Index】: R512.6
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【References】
Chinese Journal Full-text Database 3 Hits
1 Tang Qinqing,Zhou Xiaojun.Department of Pathology,Nanjing General Hospital of Nanjing Command,Nanjing 210002,China;A meta-analysis of the relation of polymorphism at the sites-1082,-592 and -819 of IL-10 gene promoter with the susceptibility to hepatitis B virus infection[J];Medical Journal of Chinese People's Liberation Army;2008-09
2 Yan Yan, Zhuo Li, Jun-Hong Li, Chun-Yan Gou, Ji-Rong Gao, Jing Shan, Xin-Hui Guo, Fang Liu, Ji-Ming Yin, Dao-Jie Liu, Xian-Chun Xie, Institute of Hepatitis, Beijing You’an Hospital, Capital University of Medical Sciences Beijing 100069, China Hong-Quan Li, Ying Liu, Hui Li, Department of Epidemi- ology, Institute of Basic Medical Sciences, Chinese Acade- my of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing 100009, China;Genetic polymorphism of interleukin-10 in patients with hepatitis B infection[J];World Chinese Journal of Digestology;2006-36
3 CHEN Xin-yue LI Zhuo HUANG Yan-xiang YIN Ji-ming YAN Yan HAO Wa LIU Fang NIU Jing-qin Beijing You'an Hospital,Capital University of Medical Sciences,Beijing 100069,China;Relationship between genetic polymorphisms of cytokine and myxovirus resistance protein A and interferon therapeutic effects in patients with chronic hepatitis B[J];Chinese Journal of Infectious Diseases;2007-11
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Quan Jun,Hu Guoling,Fan Xuegong,et al. Institute of Infectious Disease,Xiangya Hospital,Central South University,Changsha 410078;EXPRESSION OF HCV CORE PROTEIN IN HepG2 CELLS[J];China Journal of Modern Medicine;2002-20
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHAO Jie-qing~(1),Xu Jian-ming~(2),MEI Qiao~(2),et al(1.The Renmin Hospital of Huaining County,Huaining 246121;2.Dept of Gastroenterology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022);Clinical factors influencing the therapeutic response to diuretic treatment of ascites in liver cirrhosis[J];Anhui Medical and Pharmaceutical Journal;2006-10
2 XIONG Zi-zhong, CAO Hong-xia, WEI Yan-yan (Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China);Chronic severe hepatitis:clinical features of 50 patients[J];Anhui Medical and Pharmaceutical Journal;2007-01
3 LI Hai-xia, SUN Gui-rong,YAO Yuan, et al (Clinical Immunology Center, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China);CHARACTERISTICS OF HEPATITIS E INFECTION[J];Acta Acadimae Qingdao Umvesitatis;2005-03
4 JI Yang,JIA Guifang,LIU Furong,ZHENG Peng,REN Qinhui,ZHU Zhiyi,SHI Xuanling.Institute of Blood Transfusion,Chinese Academy of Medical Sciences,Chengdu 610081,China;Follow up study on blood donors infected with hepatitis C virus for 12 years[J];Chinese Journal of Blood Transfusion;2006-06
5 DANG Xi-Qiang, YI Zhu-Wen, HE Xiao-Jie, MO Shuang-Hong, Xu Zi-Chuan. Laboratory of Pediatric Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China;Liver lesions in children with hepatitis B virus associated glomerulonephritis[J];Chinese Journal of Contemporary Pediatrics;2006-04
6 HAN Da-zheng,ZHAO Zhi-jun,JIN jia-yan.The Second Department of Internal Medicine,The First Affiliated Hospital of Henan University,Kaifeng,475001,China;Study on Diagnostic Significance of Hepatic Fibrosis Histology Staging by Examing the Levels of Serum Markers[J];Journal of Chinese Physician;2003-03
7 LI Yong-zhong,FU Zheng-yuan,JIANG Jian-yong,DENG Ying,PENG Ji-jun,HU Wen-xiang,LI Huai,YU Hong-ying,MA Xiao-zheng,XIE Zhi-bing.Department of infectious disease,the First Renmin Hospital of Huaihua,Huaihua 418000,China;Effect of non-bioartificial liver on serum cytokine levels of severe hepatitis patients[J];Journal of Chinese Physician;2006-12
8 MENG Yun-yun,WANG Yao-feng,ZHONG Hong-yun(Institute of Liver Disesase,the 81th Hospital of PLA,Nanjing 210002,Jiangsu,China);Investigation on the incidence of sporadic viral hepatitis E in Nanjing from 2001 to 2005[J];Journal of Southeast China National Defence Medical Science;2007-02
9 ZHANG Ying, BIE Ping, YANG Zhan-yu, LU Qian, WANG Shu-guang, DONG Jia-hong (Institue of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Control of bleeding and coagulation during perioperative period of orthotopic liver transplantation in patients with chronic serious hepatitis B[J];Acta Academiae Medicinae Militaris Tertiae;2005-21
10 LI Yong Nian 1, GAO Jian Xing 1, LI Mei Ling 1, YANG Hong Yu 1, JIANG Hong Li 2, LIU Zheng Wen 2, LI Zhen Jiang 3 1Department of Infectious Diseases, No.323 PLA Hospital, Xian 710054, China, 2Department of Infectious Diseases, First Hospital, Xian Jiaotong University, Xian 710061, 3Hemodialysis Unit, Xijing Hospital, Fourth Military Medical University, Xian 710033, China;Treatment of chronic liver failure with molecular absorbents recirculating system: a 7-case report[J];Journal of The Fourth Military Medical University;2004-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WU Xiao-man, GUO Hai-bo. (Guangzhou Medical College, Second Affliated Hospital, Guangzhou, Guangdong, 510260);Detection and significance of interleukin 10 levels and HBVDNA in serums from patients with chronic hepatis B .[J];Chinese Journal of Clinical Hepatology;2004-03
2 MAO Xiao- rong, YUAN Hong. (Department of infection diseases , The first hospital affiliated Lanzhou Medical College, Lanzhou 730000, China);Genetic association of interleukin(IL) - 10 polymorphisms with hepatitis B in Gansu province[J];Chinese Journal of Clinical Hepatology;2005-04
3 LIU Qun,LIANG Qun,YAN Hong,et al.(Affiliated Hospital of Wuhan Science & Technology University,Wuhan,Hubei 430064,China);Association of the genetic polymorphisms of interleukin(IL)-10 with susceptibility to HBV-induced liver cirrhosis[J];Chinese Journal of Clinical Hepatology;2007-03
4 ZHANG Jian,LI Wei-ning,LIN Hua (Departmentof Laboratory Science,Shenzhen Hospital of Beijing University,Guangdong,Shenzhen,518036,China);Genetic Polymorphisms of Interleukin-10 Gene Promoter-592A/C Site with Hepatitis B Virus Infection[J];Journal of Modern Laboratory Medicine;2007-03
5 Yue-Su Zhou, Fu-Sheng Wang, Ming-Xu Liu, Lei Jin, Wei-Guo Hong, Department of Infectious diseases, Division of Bioengineering, 302 Hospital of Chinese PLA, Beijing 100039, China.;Relationship between susceptibility of hepatitis B virus and gene polymorphism of tumor necrosis factor-α[J];World Chinese Journal of Digestology;2005-02
6 Yan Yan, Zhuo Li, Jun-Hong Li, Chun-Yan Gou, Ji-Rong Gao, Jing Shan, Xin-Hui Guo, Fang Liu, Ji-Ming Yin, Dao-Jie Liu, Xian-Chun Xie, Institute of Hepatitis, Beijing You’an Hospital, Capital University of Medical Sciences Beijing 100069, China Hong-Quan Li, Ying Liu, Hui Li, Department of Epidemi- ology, Institute of Basic Medical Sciences, Chinese Acade- my of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing 100009, China;Genetic polymorphism of interleukin-10 in patients with hepatitis B infection[J];World Chinese Journal of Digestology;2006-36
7 Xiao-Zhong Wang Li-Juan Zhang Department of Gastroenterology,Union Hospital of Fujian Medical University,Fuzhou 350001,Fujian Province,China;Status of experimental and clinical research into the anti-fibrotic effects of interleukin-10[J];World Chinese Journal of Digestology;2007-23
8 Liao Riqiang, Wu Yilong, Yang Xuening, Yang Haoxian, Zhong Wenzhao Cancer Center, Department of Thoracic Surgery, Guangdong Provincial People's Hospital, Guangdong Provincial Lung Cancer Research Institute , Guangzhou 510080, P.R.China; The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R.China;Cumulate meta-analysis of the effect of platinum-basedadjuvant chemotherapy for completely resectednon-small cell lung cancer[J];The Journal of Evidence-based Medicine;2003-04
9 CHEN Qu-bo;FAN Lie-ying;ZHONG Ren-qian;TU Xiao-qing;YUAN Yuan;ZHU Ye;YE Wei-min;LU Hui-qi;HAN Huanxing The Second Institute of Clinical Medicine, Guangzhou University of TCM, Guangzhou 510120, China Corresponding author: CHEN Qu-bo.;A study on thc relationship between interleukin-10 promoter polymorphism and autoimmune liver disease[J];Chinese Journal of Hepatology;2004-06
10 Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association. 42 Dongsi Xidajie,Beijing 100710,China;The guideline of prevention and treatment for chronic hepatitis B[J];Chinese Journal of Hepatology;2005-12
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 PAN Xifeng (China Medical University,Shenyang 110001,China);Study on the progress of roles played by cytokines in type B hepatitis[J];China Medical Herald;2009-18
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Zeng Li, Zhang Jun, Li Xijie, et al. Department of Teaching and Research, Guangzhou Medical College, PLA, Guangzhou 510315$$$$[;THE CLINICAL STUDY OF HEPATITIS C VIRUS INFECTION IN HEMODIALYSIS[J];China Journal of Modern Medicine;2000-11
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