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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2005-01
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The therapeutic action of hyperoxic solution on the acute cerebral ischemia injury

Zhao Xinjing1, Zhang Yichang1, Jiang Hui2, Liu Chunran3, Xu Lixian3, Ye Ping'an1 (1. Department of Anesthesiology, First Hospital of Xi'an Jiaotong University, Xi'an 710061; 2. Department of Anesthesiology, Shaanxi Provincial People's Hospital, Xi'an 710068; 3. Department of Anesthesiology, Hospital of Stomatology, Fourth Military Medical University, Xi'an 710032, China)  
Objective To investigate protective effects of reperfusion with hyperoxic solution on acute cerebral ischemia in the rabbits. Methods A total of 18 mature domestic rabbits were randomly divided into three groups with 6 rabbits in each group: control group (CG), which was reperfused by balanced salt solution; hyperoxic solution therapy group (TG), which was reperfused by hyperoxic solution; and hyperoxic solution preconditioning group (PG). In CG group and TG group, each solution (20mL/kg) was given intravenously during reperfusion, respectively. In PG group hyperoxic solution (20mL/kg) was infused intravenously for 3 days (once a day) before ischemia. PaO 2 and the amount of MDA in plasma from internal carotid artery were determined before ischemia, in 20min after ischemia and in 45min after reperfusion, respectively. All animals were killed in 72h after reperfusion, and hippocampus CA1 were cut into slices for histopathological study. Results The amount of MDA after ischemia-reperfusion in TG group and PG group, and the number of the injured neurons in hippocampus CA1 were significantly lower than those in group CG; PaO 2 in TG group and PG group was significantly higher than that of CG. Conclusion Hyperoxic solution has some protective effects on acute cerebral ischemia.
【Fund】: 西安市社会发展科技计划项目(No.SF200229)
【CateGory Index】: R743.3
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