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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2008-01
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Effect of constant magnetic fields on intracellular free calcium of human umbilical arterial vascular smooth muscle cells

Feng Xuyang1,Xu Ruifen2,Song Bo2,Wang Haichang1(1.Department of Cardiology,Xijing Hospital,Fouth Military Medical University;2.Department of anesthesiology,Stomatology Hospital,Fouth Military Medical University,Xi'an 710032,China)  
Objective To study effects of constant magnetic fields(CMF) on the intracellular free calcium of human umbilical arterial vascular smooth muscle cells to discuss the mechanism of CMF affecting the proliferation of VSMC.Methods The intracellular free calcium concentration of human umbilical arterial vascular smooth muscle cells was detected by laser scanning confocal microsopy.Results The CMF affected the intracellular free calcium concentration of human umbilical arterial vascular smooth muscle cells.The CMF(5 mT) caused a persistent decrease of intracellular free calcium concentration of VSMC from 10 min to 50 min.Conclusion The CMF could inhibit proliferation of VSMC by decreasing the intracellular free calcium constant magnetic field concentration of VSMC.The CMF could markedly inhibit proliferation of VSMC,which might be useful in treatment of RS after PTCA.
【CateGory Index】: R35
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