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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2010-01
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Advance in research on the relationship between mTOR signaling pathway and tumors

ZHENG Peng-sheng1,2,JI Jing1(1.Department of Reproductive Medicine in Gynecology and Obstetrics,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University;2.Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education,Medical School of Xi'an Jiaotong University,Xi'an 710061,China)  
Mammalian target of rapamycin(mTOR) is a serine/threonine protein kinase that is centrally involved in the control of cell growth,proliferation,differentiation and cell cycle regulation.Recent studies have found that the mTOR pathway is complicated and the dysregulation of mTOR pathway is recognized to be associated with lots of tumors.Several inhibitors of mTOR could inhibit oncogene transformation,growth and angiogenesis of tumors.So far,four inhibitors of mTOR have been tested in clinical trials,and some have been accessed to phase Ⅱ or Ⅲ trial.Therefore,in this review,we discuss the regulators that govern mTOR pathway activity,and highlight clinical results obtained with the first generation of mTOR inhibitors to reach the oncology clinics.
【Fund】: 国家自然科学基金资助项目(No.30571951);; 国家自然科学杰出青年基金项目(No.30725043);; 教育部985-2期工程(肿瘤干细胞研究)~~
【CateGory Index】: R730.2
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