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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2010-01
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Effect of long-term nitrous oxide inhalation on the cardiac function in rats

SUN Na1,DU Jian-qing1,WANG Zhi-yong2,LIU Su-rong2,XU Yan1,ZHU Juan-xia1,LI Qiang1(1.Department of Physiology and Pathophysiology,Medical School ofXi'an Jiaotong University,Xi'an 710061;2.Department of Traditional Chinese Medicine,the Second Affiliated Hospital,Medical School of Xi'an Jiaotong University,Xi'an 710004,China)  
Objective To observe whether or not long-term inhalation of nitrous oxide can affect the cardiac function in rats.Methods Sprague-Dawley rats of either sex were randomly divided into four groups.Group A: inhaled common air for 50 days as control;Group B: inhaled 500mL/L N2O for 15 days,two hours every day;Group C: inhaled 500mL/L N2O for 30 days,two hours every day;Group D: inhaled 500mL/L N2O for 50 days,two hours every day.Float glass intracellular microelectrode recording technique was used for observation of the duration(MAPD90,MAPD50 and MAPD20) and amplitude of action potentials(APs) of left ventricular muscle cells in vitro.Angiotensin-2(Ang-2) and eNOS were detected by immunohistochemical technique.Results ① Compared with that in Group A,the Aps duration of left ventricular muscle cells(MAPD) in Group B had no significant change while the MAPDs in Group C and Group D were extended significantly.There were no significant differences among the four groups in Aps amplitude.② The expression of Ang-2 did not differ significantly between Group B and Group A.The expression level was higher in Group C and D than in Group A.③ The expression level of eNOS was significantly lower in Group C and D than in Group A(P0.05).Conclusion Long-term inhalation of N2O can significantly affect the cardiac function in rats,which may be related to higher expression of AngⅡin the heart induced by the long-time excitation of sympathetic nerves.
【Fund】: 陕西省中医管理局基金资助项目(No.2005020);; 国家自然科学基金资助项目(No.30670693)~~
【CateGory Index】: R96
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