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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2015-01
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Dynamic high expression of inositol 1,4,5-trisphosphate receptor typeⅠand its potential role in the early stage after diffuse axonal injury

JIN Tao;SONG Jin-ning;LI Yu;MA Xu-dong;GUO Xiao-ye;LIU Xiao-bin;Department of Neurosurgery,the First Affiliated Hospital,Medical School of Xi'an Jiaotong University;Department of Neurosurgery,Ankang City Central Hospital;  
Objective To detect the dynamic expression level of inositol 1,4,5-trisphosphate receptor type I(IP3R1)in rat brain stem after diffuse axonal injury(DAI)by immunohistochemistry so as to explore its potential contribution to the secondary injury after DAI.Methods Twenty-five male adult Sprague-Dawley rats were divided into the injury group(n=25)and the control group(n=5).Before immunohistochemistry detection,Golgi silver staining was performed to ensure all rats in DAI group met the criteria of DAI.Then the level of IP3R1 expression was detected by immunohistochemistry at 3 h,12 h,24 h and72 h after DAI,respectively.Results In the DAI group,a subset of axons exhibited bead-like structure,axonal retraction balls and swollen axons,and axonal axotomy was observed with Golgi silver staining.Immunohistochemical results showed mild expression of IP3R1 in the rat brain stem in the control group.After DAI the level of IP3R1 expression increased significantly.It began to increase at 3 h after injury(PI),peaked at 24 h PI,and then gradually decreased.At 72 h PI,the expression in DAI group did not significantly differ from that in the control group.Conclusion Enhanced expression of IP3R1 may participate in the calcium overload and neuronal secondary injury in the early stage after DAI.
【Fund】: 国家自然科学基金资助项目(No.30471774);; 教育部新世纪优秀人才支持计划资助项目(No.NCET-05-0831);; 陕西省自然科学基金资助项目(No.2003C1-16)~~
【CateGory Index】: R651.15
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