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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2015-01
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Application value of detection of serum hepcidin and serum transferrin receptor in maintenance hemodialysis of iron metabolism

ZHANG Yan;LI Yin-lan;CHEN Meng-hua;Department of Nephrology,the Second Affiliated Hospital of Ningxia Medical University;  
Objective To detect the changes of serum hepcidin and serum transferrin receptor(sTfR)levels in patients on maintenance hemodialysis(MHD)and those end-stage renal disease(ESRD)patients not on dialysis so as to explore their role in renal iron-deficiency anemia.Methods A total of 80 patients on MHD,80 ESRD patients not on dialysis,and 80 healthy controls were enrolled in this study.Serum hepcidin,sTfR and total ironbinding capacity(TIBC)were measured by ELISA.Serum Fe,ferritin(FER)and transferrin(TRF)were measured by routine methods.Data were compared among the groups.Results 1 Serum hepcidin and sTfR levels were significantly higher in patients on MHD and ESRD patients not on dialysis than in the healthy controls(P0.01).2 Serum hepcidin and sTfR were significantly higher in patients on MHD than in ESRD patients not on dialysis(P0.05).3 Pearson correlation analysis revealed that serum hepcidin was positively correlated with Scr(r=0.515),hs-CRP(r=0.312),serum Fe(r=0.290)and FER(r=0.286)(all P0.01);but negatively correlated with HGB(r=-0.466),eGFR(r=-0.362),HCT(r=-0.285),TRF(r=-0.248)and TIBC(r=-0.224)(P0.05).4 Pearson correlation analysis revealed that sTfR was positively correlated with HGB(r=0.378)and HCT(r=0.514)(both P0.01),but negatively correlated with FER(r=-0.764)and TSAT(r=-0.519)(both P0.01).5 The area of serum hepcidin,sTfR and FER or TSAT under the ROC curve was90.8%,and the sensitivity and specificity were 93.3% and77%,respectively.Conclusion Serum hepcidin,sTfR and ferritin or transferrin saturation is important for assessing and treating ESRD patients with renal iron-deficiency anemia.
【Fund】: 宁夏自然科学基金资助项目(No.NZ13202);; 宁夏医科大学科学研究基金资助项目(No.XM2012036)~~
【CateGory Index】: R692.5
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