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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2015-01
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Actesoide induces heme oxygenase-1 expression through activating ERK1/2 pathway

WANG Hong-quan;WANG Yu-min;CUI Qi-fu;ZHAO, Wei-li;WANG Li-na;ZHANG Jun-yi;Chifeng Medical College,Chifeng University;Department of Neurology,the Affiliated Hospital of Chifeng Uinversity;Department of Oncology,the Affiliated Hospital of Chifeng Uinversity;Department of Pathology,the Affiliated Hospital of Chifeng Uinversity;  
Objective To investigate the molecular mechanism for actesoide inducing heme oxygenase-1(HO-1)expression through activating ERK1/2 pathway.Methods Cultured PC12 cells were treated with preincubated with or without ERK1/2 inhibitor,PD98059.The expressions of pERK1/2,ERK1/2 and HO-1 protein were measured by Western blot.Results Actesoide induced the upregulated expression of HO-1 in a concentrationdependent manner.Actesoide activated the ERK1/2 cascade.Actesoide treatment resulted in time-related induction of the phosphorylation of ERK1/2 in PC12 cells.Actesoide-induced HO-1 expression was blocked by ERK1/2inhibitor PD98059 in a concentration-dependent manner.Conclusion Actesoide induces HO-1 expression through activating ERK1/2 pathway.
【Fund】: 国家自然科学基金项目资助项目(No.81260196 81450036 81201844);; 内蒙古自治区高等学校青年科技英才支持计划(No.NJYT-13-B20);; 内蒙古自治区高等学校科学研究项目(No.NJZZ12306 NJZZ14271);; 国家社科基金项目(No.13CRK009);; 内蒙古自然科学基金项目(No.2014MS0892 2014BS0802 2014MS0814 2013MS1176)~~
【CateGory Index】: R285
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