Effects of Shen-kang injection on blood pressure and related factors of hypertensive renal disease rats
ZHOU Nan;L Yan-ying;WANG Hong-ying;WANG Jun-ping;WANG Guang-jian;ZHAO Xing;YANG Jian;HE Jian-yu;School of Pharmacy,Xi'an Jiaotong University;Xi'an Shiji Shengkang Pharmaceutical Industry Co.Ltd.;Department of Clinical Epidemic Prevention,Police Headquarters of Armed Forces;
Objective To observe the effects of Shen-kang injection on blood pressure and related factors in hypertension nephropathy rats.Methods Thirty-two male rats with hypertension nephropathy were randomly divided into 4 groups:model group,positive control group,and Shen-kang low-and high-dose injection groups.WKY rats served as the negative control group.The positive control group was treated with fosinopril sodium(1.6mg/kg)by intraperitoneal injection.Shen-kang injection groups were treated with intraperitoneal Shen-kang injection containing 4.8 and 2.4 g/kg of crude drug respectively.Negative control group and model group were injected with normal saline of the same volume.Drugs were administered once a day for 30 consecutive days.The blood pressure,cardiac abnormalities and related inflammatory factors such as NO,Ang-Ⅱ,C-reactive protein and TGF-β1 were determined after the last administration.Results Rat body weight of each group did not significantly differ during the administration(P 0.05).Compared with that in model control group,blood pressure was significantly lowered in Shen-kang injection groups after administration(P0.05 or P0.01).NO activity was increased while renal cortex Ang-Ⅱ was reduced and C-reactive protein was decreased obviously(P 0.05).However,serum Ang-Ⅱ and TGF-β1levels were not significantly different in Shen-kang injection groups(P 0.05).Conclusion Shen-kang injection can lower blood pressure,improve NO activity,and decrease Ang-Ⅱ and C-reactive protein levels in rats with hypertension nephropathy.
【CateGory Index】： R285.5