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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2017-02
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Expressions of matrix metalloproteinases and their inhibitors in steroid-induced necrosis of rat femoral head

ZHAO Hong-xing;HUANG Yuan-xia;XU Hai-bin;WU Da-peng;WANG Lei;Department of Orthopedics,the First Affiliated Hospital of Xinxiang Medical University;Department of Orthopedics,the Affiliated Luohu Hospital of Shenzhen University;Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences;  
Objective To study the protein expression levels of matrix metalloproteinases(MMPs)and their inhibitors in bone tissues of rat femoral head and to explore the relationship between necrosis of femoral head and glucocorticoid.Methods Twenty healthy adult SD rats were randomly divided into glucocorticoid group and control group,with10 rats in each.Glucocorticoid group was treated with intramuscular injection of hydrocortisone twice a week.The control group received normal saline of the same volume.Four weeks later,bone tissues of left femoral head were collected from each group of rats for HE determination of femoral head necrosis.The expressions of matrix metalloproteinase-1(MMP-1), matrix metalloproteinase-2(MMP-2),tissue inhibitor of matrix metalloproteinase-1(TIMP-1),and tissue inhibitor of matrix metalloproteinase-2(TIMP-2)at mRNA and protein levels were detected by RT-PCR and Western blot techniques,respectively.Results The expressions of MMP-1and MMP-2 at mRNA and protein levels were higher in glucocorticoid group than those in the control group.However,TIMP-1 and TIMP-2 gene and protein expression levels were lower in glucocorticoid group(all P0.05).Conclusion The expressions of MMPs in bone tissues of rat femoral head in early necrosis were increased,but their inhibitors had decreased expressions.We can draw the conclusion that glucocorticoid-induced necrosis of femoral head may be related to its regulation of the expression levels of MMPs and their related inhibitors.
【CateGory Index】: R681.8
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【Citations】
Chinese Journal Full-text Database 7 Hits
1 Zhao Zhen-qun;Zhang Zhi-feng;Liu Wan-lin;Bai Rui;Wang Wen-xuan;Sun Liang;Department of Pediatric Orthopedics, the Second Affiliated Hospital of Inner Mongolia Medical University;Department of Joint Surgery, the Second Affiliated Hospital of Inner Mongolia Medical University;Department of Hand and Foot Surgery, the Second Affiliated Hospital of Inner Mongolia Medical University;;Hypoxia inducible factor-1 alpha and apoptosis of osteocytes in steroid-induced avascular necrosis of the femoral head[J];中国组织工程研究;2015-51
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3 Ma Jing;Guo Xiong;Shi Xiaowei;Wu Shixun;Zhang Zengtie;Zhang Qiang;Faculty of Health Care,the First Hospital of Medical Collage of Xi'an Jiaotong University;;Expression changes of matrix metalloproteinases and tissue inhibitor of metalloproteinases in the articular cartilage of patients with Kashin-Beck disease[J];中华地方病学杂志;2015-05
4 Peng Hao;Chen Sen;Li Jianping;Zhou Jianlin;Fang Hongsong;Department of Orthopedies,Renmin Hospital of Wuhan University;;Erythropoietin prevents rats from glucocorticoid-induced osteonecrosis of the femoral head via antiapoptosis[J];中华实验外科杂志;2014-11
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【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 CHEN Bao-lang;Physiology Teaching and Research Section,Heze Medical College;;Research progress of apoptosis in the pathogenesis of glucocorticoid-induced necrosis of the femoral head[J];中国当代医药;2016-19
2 ZHU Li-hua;ZHU Bao-hua;LIU Min-bo;Department of Orthopedics The First People's Hospital of Xiaoshan District;;Application value of atorvastatin combined with anticoagulation drugs in elderly patients with steroid-induced avascular necrosis of the femoral head[J];中国生化药物杂志;2016-06
3 Zhang Chen;Ma Jianqiang;Old Palace Hospital Beijing;;Effects of Jiawei Yanghe decoction for knee osteoarthritis patients MMP-3,MMP-9 level[J];陕西中医;2016-02
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