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《Journal of Xi'an Jiaotong University(Medical Sciences)》 2017-02
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Analgesic effect of radiofrequency ablation on the serum levels of TNF-α,IFN-γ and IL-17 in patients with lumbar disc herniation

WANG Hui;LI Na;WANG Suo-liang;BU Gang;Department of Rehabilitation Medicine,the First Affiliated Hospital of Xi'an Jiaotong University;  
Objective To investigate the effect of radiofrequency ablation on serum tumor necrosis factor alpha-α(TNF-α),interferon gamma-γ(IFN-γ)and interleukin 17(IL-17)levels in patients with lumbar disc herniation.Methods We studied276 patients with lumbar disc herniation admitted to the First Affiliated Hospital of Xi'an Jiaotong University from January 2010 to December 2015.The experimental group received radiofrequency thermocoagulation and target ablation decompression treatment.In the same period,133 healthy subjects were selected as control group.We collected the general information of the admitted patients and their serum before and after operation as well as serum of the control group.The changes of TNF-α,IFN-γand IL-17 levels were detected by ELISA method.Results The levels of serum TNF-α,IFN-γand IL-17 in the patients with lumbar disc herniation were significantly higher than those in the control group(P 0.05).Compared with those before operation,the serum levels of TNF-α,IFN-γand IL-17 were decreased significantly in the recovery phase after radiofrequency ablation(P0.05).Conclusion Frequency thermal coagulation target ablation decompression treatment of lumbar disc herniation can not only improve pain symptoms but also reduce the systemic inflammatory reactions.Therefore,it deserves clinical application.
【CateGory Index】: R681.53
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