Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Xi'an Jiaotong University(Medical Sciences)》 2017-02
Add to Favorite Get Latest Update

The inhibitory effect of Rompun anesthesia and operation on immune function of dogs

GUO Jian;NAN Yong-shan;Department of Anesthesia,the Affiliated Hospital of Yanbian University;  
Objective To study the inhibitory effect of Rompun anesthesia and operation on immune function of dogs.Methods We randomly divided 14 healthy dogs into Group A and Group B with 7 in each.Rompun anesthesia induced by intramuscular injection of 3.0mg/kg Rompun was carried out in Group A while Rompun anesthesia and operation were applied in Group B.The venous blood samples were collected before and after anesthesia at 2,8,24,72,120 and 168 h for centrifugation to obtain sera.ELISA kit was used to evaluate the contents of serum IL-1β,IL-2,IL-4,IL-8 and TNF-α.Results Compared with those before anesthesia,the concentrations of IL-2,IL-1βand TNF-αin Group A significantly decreased at 2,8,24 and 72 h(P0.05)and resumed the pre-anesthesia level from120 to 168 h;however,the concentrations of IL-4 and IL-8 did not change significantly during 2 to 168 h(P0.05).Compared with those before anesthesia,the concentrations of IL-2 and IL-1βin Group B significantly decreased from2 to 168h(P0.05),while the concentrations of TNF-αand IL-8significantly increased(P0.05).IL-2 and IL-1βcontents in Group B from2 to 168 h were significantly decreased compared with those in Group A(P 0.05),whereas IL-8 and TNF-αincreased significantly(P 0.05).Conclusion Both Rompun anesthesia and operation stress can inhibit dogs'immune function,and the latter has a stronger inhibitory effect than the former.
【CateGory Index】: S859.791
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved