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《Journal of Cellular and Molecular Immunology》 1992-01
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Screening of McAbs against Different Epitopes of "α"Determinant of HBsAg and Study on Their Characteristics

Wang Youchun Li Hemin Hu Zonghan ( Department of Hepatitis, National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050 )  
Five McAbs against different epitopes of "α" determinant of HBsAg were selected from sixteen McAbs by competitive inhibition assay The five McAbs were B6 B9, B12, B13, and A1 Four McAbs ( B6, B9, B12, and A1 ) were compared with two other McAbs ( RF1 and RF7 ) It was shown that McAbs B6, B9 and Bl2 were similar to RFr and none of the McAbs was similar to RFl It was also found using Western blot test that polyclonal anti-HBs antibody and McAbs Bl3 and Al might combine with both glycosylated monomer ( GP27 ) and nonplycosylated monomer ( P24 ) of HBsAg. However, McAbs B6, B9 and B12 might combine only with nonglycosylated monomer ( P24 ) , but not with glycosylated monomer ( P27 ) of HBsAg.
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