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《Journal of Cellular and Molecular Immunology》 1992-01
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Protection against Lethal Challenge of BALB/c Mice by Passively Transferred Monoclonal Antibodies to Glycopro-teins of Herpes Simplex Virus

Liu Xueyan.Wang Meixian Qin Kefeng Huang Jan Yu Qigui Zheng Renrui (Department of Microbiology, 4th Military Medical: University, Xi'an 710032 Department of Microbiology, Medical Training School GLD, Beijing 100071)  
BALB/c mice were intraperitoneally challenged with the SM44 strain of HSY-1 and the say strain of HSV-2, respectively. At the time of challenge or 24 hou- rs later, 6 monoclonal antibodies directed against glycoproteins of herpes simplex virus were administered intraperitoneally for evaluation of their passive protection of the animals against lethal challenge. It was found that 4 McAbs ( 2C5, 1A12, Mad-2 and 1D10.) might protect against HSV-1 infection while 5 McAbs ( 2C5, 1A12, 2A8, 1D10 and CH-A9 ) might protect against HSV-2 infection. A direct correlation was observed between in vitro neutralization and in vivo protection, protection against HSV infection by the monoclonal antibodies was analyzed by neutralization tests with or without complement participation. The results confirmed that the glycoproteins of herpes simplex virus expressed both type-common and type-specific determinants during the course of acute virus infection in vivo.
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 Yu Qigui, et al. Department of Microbiology, Fourth Military Medical college, Xi'an 710032, China;Identification of glycoprotein C of herpes simplex virus[J];中国免疫学杂志;1990-06
2 Cao Qian et al(Dept. Microbiology, The Fourth Military Medical College, Xian);THE PRODUCTION OF AN ANTI-NSV-1 LYMPHOCYTE HYBRIDOMA CELL LINE AND TYPING OF HSV ISOLATES WITH MONOCLONAL AHTIBODIES[J];病毒学杂志;1986-04
3 Gao Qian and Shen Qian. Under the guidance of Wang Meixian. Department of Microbiology, Fourth Military Medical College, Xi-an;ESTABLISHMENT OF THE HYBRIDOMA CELL LINES SECRETING MONOCLONAL ANTIBODIES AGAINST THE HERPES SIMPLEX VIRUS[J];解放军医学杂志;1985-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Liu Junlian, Wang Detang, Wang Hongying, et al. Department of Dermatology, 306 Hospital of PLA, Beijing, 100101;Detection and typing of herpes simplex virus DNA in genital specimens from female patients by antigen capture polymerase chain reaction[J];中国麻风皮肤病杂志;2003-06
2 YANG Qiao-xin , MA Wen-yu , YU Ying (Department of Microbiology, Fourth Military Medical University, Xi'an 710032, China);Screening of HSV glycoprotein C mimotope binding to McAb 1A12[J];免疫学杂志;2002-02
3 Jian Yu, Yinghua Zhang, Donggao Zhang Department of Ophthalmology, Tangdu Hospital Fourth Military Medical University, Xian 710038, China;In Vivo Observations and Electron Microscopy of Treatment of Experimental HSV Keratitis with Anti-HSV Monoclonal Antibodies[J];眼科学报;1996-03
4 Yu Qigui, Qin Kefeng. Liu Junlian, et al Department oj Microbiology, Fourth Military Medical University,Xi'an 710032;EXPRESSION OF SINGLE DOMAIN ANTIBODY AGAINST HSV GLYCOPROTEIN IN INSECT CELLS USING BACULOVIRUS AS A VECTOR——CONSTRUCTION OF RECOMBINANT BACULOVIRUS 1A12VH-AcNPV[J];中华微生物学和免疫学杂志;1995-03
5 Liu Xueyan.Wang Meixian Qin Kefeng Huang Jan Yu Qigui Zheng Renrui (Department of Microbiology, 4th Military Medical: University, Xi'an 710032 Department of Microbiology, Medical Training School GLD, Beijing 100071);Protection against Lethal Challenge of BALB/c Mice by Passively Transferred Monoclonal Antibodies to Glycopro-teins of Herpes Simplex Virus[J];细胞与分子免疫学杂志;1992-01
6 Qin Kefeng, Yu Qigui, Yang Lianghu, Wang Meixian, Hang Shaozhun(Department of Microbiology, The Fourth Military Medical University, Xian, Shaanxi 710032);Characterization of Herpes Simplex Virus Glycoproteins and Clinical Application of Monoclonal Antibodies to Herpes Simplex Virus[J];细胞与分子免疫学杂志;1991-01
7 Zhao Yukuen, et al (Dept · of Microbiology);THE ESTABLISHMENT OF HYBRIDOMA CELL LINE OF MONOCLONAL ANTIBODY SECRETING HSV-Ⅱ[J];中国医科大学学报;1989-06
8 Wang Meixian,Gao Qian,Qin Kefeng,Shen Qian and Tang Jiaqi Laboratory of Molecular Virology,Department of Microbiology;Study and Application of Monoclonal Antibodies against Herpes Simplex Virus[J];第四军医大学学报;1989-04
9 Gao Qian, et al. Department of Microbiology;Antigenic Analysis of Herpes Simplex Virus with Monoclonal Antibodies[J];第四军医大学学报;1988-04
10 Jian Yu;Yinghua Zhang;Donggao Zhang Department of Ophthalmology, Tangdu Hospital Fourth Military Medical University. Xian 710038. China;In Vivo Observations and Electron Microscopy of Treatment of Experimental HSV Keratitis with Anti-HSV Monoclonal Antibodies[J];Eye Science;1996-03
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Wang Haitao(Department of Microbiology);Preparation of Enzyme-Labelled Anti-Human IgM McAbs and Their Preliminary Characterization and Application[J];第四军医大学学报;1987-06
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