Role of cytokine imbalance mediated by nitric oxide in pathogenesis of chronic lymphocytic thyroiditis in children
DONG Wen bin,RAN Long rui,XIAO Da chengDepartment of Pediatrics, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
Aim To probe the role of serum nitric oxide(NO)in invasion of chronic lymphocytic thyroiditis(CLT) as a mediator of cytokine imbalance. Methods NO concentration and IFN γ/IL 4 levels produced by PBMC, and their relationships to thyroidal function were investigated in 13 children with CLT. Results NO concentration and IFN γlevel were significantly increased(P0.01), while IL 4 level was markedly decreased(P0.01) compared with the control group. There were strong positive correlations between NO concentration and the levels of IFN γand TSH(P0.05). There were strong negative correlations between the NO concentration and the levels of IL 4, T3 and T4(P0.05). Conclusion NO could be involved in the development of chronic lymphocytic thyroiditis as a mediator of cytokines imbalance.