The effects of vascular endothelial growth factor on dendritic cells in esophageal tumor tissue
YANG Wen-feng~1, LI Dao-tang~1, LI Jing~1, CHEN Xu-xia, WAGN Shan-zheng~2 ~1Thoracic Surgery Department of Shandong Cancer Hospital, Jinan 250117; ~2Thoracic Surgery Department of Qilu Hospital of Shang dong University, Jinan 250012, China
AIM: To investigate the relationship between vascular endothelial growth factor (VEGF) and S100 protein positive dendritic cell (DC) in esophagelal tumor tissue. METHODS: VEGF and S100 protein in 94 patients with esophageal carcinoma were detected by HRP Labelled streptavidin biotin(LSAB) immunohistochemical method. RESULTS: Postive rate of VEGF in esophageal tumor tissues was 74.46%(70/94); and the later the clinical stage and the lower the differentiation level was the more VEGF was(r=0.864, 0.803, respectively; P0.05 ); while the later the clinical stage and the lower the differentiation level was, the less number of S100~+DCs existed (r=-0.763, -0.908 , respectively; P0.05). Furthermore, there was a reverse correlation between the expression of VEGF and S100~+ DC (r=-0.817, P0.05). CONCLUSION: There may be a reverse relationship between the expression of VEGF and S100~+ DC in esophageal tumor tissue, VEGF could decrease the number of S100~+ DC and impair the immunological function of the body.