Preventive and therapeutic effects of qiongyugao on hepatocellular carcinoma via inhibitionoftheexpressionof HBxAg in hepatic carcinoma cells
CHEN Xiao-yin~ 1* , WEI Chun-shan~3, TONG Guang-dong~4, MAO Hui-jun~1, XIA Fang~1, JIANG Zhen-you~2 ~1Department of Traditional Chinese Medicine, ~2Department of Microbiology and Immunology, Medical College, Jinan University, Guangzhou 510632; ~3Department of Infection, Zengcheng People’s Hospital, Zengcheng 510000; ~4Department of Hepatopathy, Shenzhen Traditional Chinese Medical Hospital, Shenzhen 518000, China
AIM: To investigate the effects of qiongyugao on the expression of hepatitis B x antigen (HBxAg) in BALB/c-nu mice into which human hepatic carcinoma cells were transplanted, and to analyze its specific mechanism in prophylaxis and treatment of hepatocellular carcinoma. METHODS: A nude mouse model with the transplantation of human hepatic carcinoma cells was established to observe the preventive and therapeutic effects of qiongyugao on the body weight and tumor weight of the mice. The expression of HBxAg in tumor and liver tissue wsa detected by immunohistochemical studies. RESULTS: Compared with model control group, prophylaxis and treatment with qiongyugao increased the body weight, depressed the tumor weight and inhibited HBxAg expression. The same efficacy was showed in both qiongyugao prophylaxis group and cyclophosphamide treatment group. CONCLUSION: Qiongyugao canslowdownthegrowthoftumorandinhibitthe expression of HBxAg, which may be an essential mechanism in prophylaxis and treatment of hepatocellular carcinoma.