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《Chinese Journal of Cellular and Molecular Immunology》 2010-01
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Relationship between the level of MCP-1 expression in sera of RA patients and ILD

LING Tao1,Lü Hao-zhe2,MA Yu-xia1,SHANG Qing-hui3,ZHANG Jin-tao1,LU Jing1 1Department of Rheumatology and Immunology,the First Affiliated Hospital,China Medical University,Shenyang 110001;2Department of Rheumatology and Immunology,Daqing Oilrield General Hospital,Daqing 163001;3Hulunbeier People Hospital,Hailaer,Inner Mongolia 021008,China  
AIM:To investigate the function and clinical significance of monocyte chemoattractant protein-1 MCP-1 in the pathogenesis of rheumatoid arthritis(RA)and the relation ship between the expression of MCP-1 in serum and interstitial lung disease(ILD)secondary from RA.METHODS:60 patients with RA were divided into two groups:30 cases with simple RA group and 30 cases with ILD secondary from RA(RA+ILD group).The control group incuided 20 healthy cases.Enzyme linked immunosorbent assay(ELISA)was used to determine the serum expression of MCP-1 in patients healthy controls.The differences of MCP-1 level and other laboratory indexes(IgG,IgA,IgM,α2-G,γ-G,RF,ESR,CRP,and the number of arthrocele)in different groups were compared with software spss13.0.RESULTS:The expression of MCP-1 in simple RA patients was significantly higher than that in the control group(P0.05)and significantly lower than that in the RA+ILD group(P0.01).The level of MCP-1 in serum of RA patieuts was positively correlated with IgG,IgM,and γ-G.CONCLUSION:MCP-1 plays an important role in the pathogenesis of RA and may contribute to the promotion of lung fibrosis in ILD secondary from RA.
【Fund】: 辽宁省教育厅高校科研项目资助计划(20060997)
【CateGory Index】: R593.22
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