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The expression and clinical significance of Annexin Ⅱ in clear-cell renal cell carcinoma

YANG Jin1,CHENG Ting-ting1,WANG Li-na1,CHEN Wei2,LI Xu2 1Department of Medical Oncology,2Center Laboratory of Molecular Biology,the First Affiliated Hospital,Medical College of Xi' an Jiaotong University,Xi' an 710061,China  
AIM:To discuss the difference of annexinⅡ expression between the Clear-Cell Renal Cell Carcinoma(ccRCC) and the corresponding normal renal tissues,and to reveal the clinical significance of Annexin Ⅱ expression in ccRCC.METHODS:Western blotting was used to detect the expression of Annexin Ⅱ in 29 samples of fresh ccRCC and the corresponding normal renal tissues.Annexin Ⅱ expression was examined in 120 samples of paraffin-embedding ccRCC and the corresponding normal renal tissues using immunohistochemistry.Correlations with Annexin Ⅱexpression and clinic-pathological parameters were analyzed.RESULTS:There was expression of Annexin Ⅱ in both ccRCC and the corresponding normal renal tissues.In ccRCC tissues,the total levels of Annexin Ⅱ proteins were significantly higher than that in the corresponding normal renal tissues(P0.01).The positive rate of AnnexinⅡ expression in immunohistochemistry was 67.5% in the ccRCC tissues,existing significant difference compared with the corresponding normal renal tissues(P0.01).Expression of Annexin Ⅱ in ccRCC mainly showed membranous staining.Annexin Ⅱ expression level was positively correlated with TNM stage(P0.05),histology grade(P0.05),renal capsule infiltration(P0.01) and distant metastasis(P0.01) of ccRCC.Moreover,Annexin Ⅱ expression level was significantly correlated with ccRCC patients′5-years survival rate(P0.01).CONCLUSION:Overexpression of AnnexinⅡ in the ccRCC is closely correlated with the ccRCC development.It may play an important role in the process of ccRCC invasion and metastasis.
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