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《Chinese Journal of Cellular and Molecular Immunology》 2014-01
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Expressions and clinical significances of iASPP and caspase-9 in esophageal cancer

KOU Wei;DOU Chunjiang;LAN Yongmei;GU Qiaoling;Medical College,Northwest University for Nationalities;  
Objective To investigate the expressions of inhibitory member of the apoptosis stimulating protein of p53 family( iASPP) and caspase-9 in the esophageal cancer( EC) tissues and their correlations with clinical pathological parameters. Methods Using streptavidin-peroxidase( SP) immunohistochemistry and reverse transcription PCR( RTPCR),the protein and mRNA expressions of iASPP and caspase-9 were detected in 85 EC samples and 30 normal esophagus tissues to analyze their relationships with the clinicopathologic parameters of EC. Results The positive expression rate of iASPP was significantly higher in EC than that in normal esophagus tissues by SP( 72. 9% vs 16. 7%,P 0. 01) and by RTPCR( 0. 657 ± 0. 115 vs 0. 321 ± 0. 065,P 0. 01). However,The positive expression rate of caspase-9 was significantly lower in EC than that in normal esophagus tissue by SP method( 18. 8% vs 76. 7%,P 0. 01) and by RT-PCR( 0. 297 ± 0. 058 vs 0. 593 ± 0. 108,P 0. 01). The mRNA expression levels of iASPP and caspase-9 in EC were significantly related to the invasive extent,histological differentiation,TNM stages,and lymphatic metastases( P 0. 05),but not related to the age, sex,tumor size and pathological type( P 0. 05). The expression of iASPP mRNA was negatively correlated with caspase-9( r =-0.382,P 0. 05). Conclusion The overexpression of iASPP and the low expression of caspase-9 in EC are closely correlated with tumor invasion and metastasis,and iASPP may promote the progression of EC through inhibiting the expression of caspase-9.
【Fund】: 西北民族大学中央高校基本科研业务费专项资金资助项目(zyz2012094);; 甘肃省教育厅科研项目(1118B-02)
【CateGory Index】: R735.1
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Chinese Journal Full-text Database 2 Hits
1 Chen Jie;Yang Yimin;Yang Liangliang;Yang Ting;Cai Yun;Xin Haiming;Liu Zejun;Department of Clinical Laboratory,the 16th Hospital of PLA;Laboratory of International Cooperation,Southwest Hospital,Third Military Medical University;;Construction of eukaryotic expression vector of iASPP and its identification of biological function[J];Chongqing Medicine;2013-35
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Chinese Journal Full-text Database 3 Hits
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