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Prediction and evolution of B cell epitopes of hemagglutinin in human-infecting H6N1 avian influenza virus

YANG Jianke;YUAN Jian;GAO Jiguang;ZHU Xiaolei;LIN Aiqin;Department of Medical Biology,Wannan Medical College;College of Life Sciences,Anhui Normal University;  
Objective To predict B cell epitopes of hemagglutinin(HA) of human-infecting H6N1 avian influenza virus and analyze their evolutionary characteristics.Methods The dataset was downloaded from GISAID and Gen Bank databases.And the linear and conformational B cell epitopes of HA were predicted separately by various bioinformatic software.Furthermore,the conservation,adaptation and other evolutionary characteristics were also analyzed by some bioinformatic means.Results Four linear epitopes(A,B,C and D) and two conformational epitopes(E and F) were obtained after consideration of multiple factors.And the C epitope and sites(41,157,186,187) mutated easily,but the other epitopes were very conservative and the D epitope was the most conservative.Interestingly,the site 157 was identified under positive selection,suggesting that it may be a particularly important site to make the virus evade the attack from the host immune system.Conclusion The HA of human-infecting H6N1 avian influenza virus has five conservative B cell epitopes(three linear and two conformational) and one site under positive selection.The findings would facilitate the vaccine development,virus control and pathogenesis understanding.
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