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High expression of cyclin D1 is correlated with the expression of estrogen receptor and good prognosis in breast cancer

YANG Chengcheng;NAN Kejun;ZHANG Yamin;CHEN Yimeng;QIN Sida;Department of Oncology,First Affiliated Hospital,School of Medicine,Xi'an Jiaotong University;Department of Thoracic Surgery,First Affiliated Hospital,School of Medicine,Xi'an Jiaotong University;  
Objective To explore the expression levels and clinical significance of cyclin D1 and estrogen receptor( ER)in breast cancer. Methods Immunohistochemical staining was performed to detect the expression levels of cyclin D1 and ER in 102 breast cancers and 60 normal breast tissue specimens. Referring to clinicopathological parameters and 5-year follow-up data,we analyzed the correlations between cyclin D1,ER and their prognosis. Results The expression levels of both cyclin D1 and ER were significantly different between breast cancer and normal breast tissues. Cyclin D1 expression was related to tumor histological grade,TNM stage and ER levels. Spearman correlation analysis showed that cyclin D1 and ER were positively related. Moreover,Kaplan-Meier analysis showed that patients who expressed high levels of cyclin D1 had a longer overall survival compared with those with low expressions. Cyclin D1,ER,and TNM stage were independent prognosis factors according to Cox analysis. Conclusion Cyclin D1 has a higher expression in breast cancer,positively correlated with ER and better prognosis.
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