The Preliminary Observation on the Dynamics of Murine McAb in JE Patients
Huang Qing'vheng;Ma Wenyu; Jiang shaozhun and Yu Biyun(Microbiology Department,of the Fourth Military Medical University,Xi'an 710032)
Japanese encephalihs patientS'blood were collected at the 3rd hour, 3rd day,7th day,10thday,and 14th day after receiving 5 mg of JEV McAb by i,v. The murine McAb IgG was purified andqualified according to the standard of quality control for the use of murine McAb in human body issued by the Ministry of Health.We obtained a curve in which JEV--McAb concentration in blood was1μg/ ml at 3rd hour,0.7μg/ ml at 3rd day,0.15 μg/ ml at 7th day after administration of theMcAb,and it was found the half-life of JEV-McAb in blood was 4 days. Another result showed thatanh- McAb antibody could be detected by ELISA in 4 patients while the others were negative.