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Effects of Interleukin-11 on Mouse Hematopoiesis

Sun Kai;Jin Boquan;Zhu Yong; LI qi;Liu Yuesong;Dong Bangqucn and Zhangjianpihg(Department oflmmunology,The Fourth Military Medical University, Xi'an 710032)Liu Xin(Department of Molecular Biochemistry, The Third Military Medical University, Chongqing63003  
interleukin-11(IL-11) is a multifunctional cytokine especially in hematopoiesis.In thisPaper, we used recombinant human IL-11 secreted by hIL-11 cDNA transfected murine fibroblast cellline,NIH-3T3 cells to identify itS effectS on proliferahon and colony-forming activity of mouse bonemarrow progenitor cells .ResultS showed that IL-11 synergetically enhanced the Meg--CFU andMix-CFU formation with IL-3,suggesting that IL-11 could be a POtential cytokine in cytokinetherapy for treatment of hematopoietic disorders.
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