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Function Assay for Therapeutic Anti human T Lymphocytes Monoclonal Antibody

Sun Kefang, et al. (Wuhan Institute of Biological Products, Wuhan 430060)  
The intradermal GVHR in rabbits were studied to evaluate the immunosuppressive effects of the anti human T lymphocyte McAbs, WuT 3 and OKT 3 The influential factors of the experiment, such as the effects of FCS and cyclophamide on GVHR, relationship between the concentration of PBL and the strength of reaction, and the time of peak reaction, were observed and compared The GVHR test was established and stabilized The experiment shows that both WuT 3 and OKT 3 can inhibite the GVHR Finally, the validity of combination use of WuT 3 and WuT 4 was preliminarily evaluated
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