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《Journal of Northwest Sci-Tech University of Agriculture and Forestry》 1989-03
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THE ISOLATION AND IDENTIFICATION OF TOXIC COMPONETS FROM OXYTROPIS OCHROCEPHALA

Cao Guangrong Li Shaojun Duan Dexian (.Department of Veterinary Medicine,Northwestern Agricultural University)Russell J.Molyneux (USDA Western Regional Research Center)Zhao Xiaowen (Xian 204 Research institute')  
The indolizidine alkaloid Swainsonine which inhibits a -mannosiciase has been isolated from 0. ochrocephaia in this experiment, plasma a -nran-nosidase of goats poisoned by feeding O. ochrocephaia was significantly lower than that of normal control animals(p0.01) After O, ochrocephaia feeding stopped,the goats poisoned recovered from their illness gradually,and plasma a -mannosidase returned to normal conditions rapidly. Swainsonine analysis of the plant samples showed that Swainsonine ranges of O.ochrocephaia and Q.kansucnsis were 0-012% and 0-021% (D.W) respectively. Therefore, it is considered that the swainsonine is the principal toxic component of O,ochrocephaia and O.kansuensls.
【Fund】: 国家自然科学基金
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