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《Journal of Northwest A & F University(Natural Science Edition)》 2019-01
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Effect of platycodin D on lymphocyte and macrophage immune function of mice

LI Jingshuang;FENG Huihui;WANG Meng;YU Yang;College of Animal Husbandry and Veternary Medicine,Jinzhou Medical University;  
【Objective】The study investigated the effects of platycodin D on immune function of lymphocyte and macrophage of mouse.【Method】The lymphocytes and macrophage suspensions were prepared through sterile isolation of mouse spleen lymphocytes and peritoneal macrophages.Two types of cells were cultured separately with blank control group,positive control group(cells were treated by levamisole),and four experimental groups with platycodin D concentrations of 25,50,75 and 100μg/mL.The effects of platycodin D on lymphocyte proliferation and macrophage phagocytosis were detected by MTT assay.The effects of platycodin D on secretion of IL-2and IL-4in lymphocyte and secretion of TNF-αand IL-12 in macrophages were detected by ELISA.【Result】Platycodin D promoted lymphocyte proliferation,enhanced phagocytosis of macrophage,and stimulated secretion of IL-2and IL-4in lymphocyte and secretion of TNF-αand IL-12 in macrophages.The concentration of 50μg/mL was the best.【Conclusion】Platycodin D enhanced the immunomodulatory activities of mouse lymphocytes and macrophages.
【Fund】: 辽宁省自然科学基金项目(20170540369);; 2017年国家级“大学生创新创业训练计划”项目(201610160011)
【CateGory Index】: R285.5
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