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《Journal for China AIDS/STD》 2003-01
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Expression of CD_(38) HLA-DR on CD_4~+ and CD_8~+T lymphocytes in peripheral blood of people living with HIV/AIDS

WANG Xi-cheng,WU Hao,LI Tai-sheng,et al.(Division of Infectious Diseases,Beijing Youan Hospital,Beijing 100054,China)  
Objective This study was designed to investigate the change in expression of CD 38 HLA-DR on CD + 4 and CD + 8 T lymphocytes in peripheral blood of people living with HIV/AIDS and to explore clinical significance of such change.Methods The plasma viral load of 11 asymptomatic HIV infected individuals and 18 AIDS patients was detemined by bDNA.Expression of CD 38 HLA-DR on peripheral blood CD + 4 and CD + 8 T lymphocytes was analysed by flow cytometry in 51 healthy blood donors,14 asymptomatic HIV infected individuals and 36 AIDS patients.Results Percentage of CD + 4 HLA-DR+ cells in the AIDS group was shown to be higher than in the HIV group and normal controls.Percentage of CD + 8HLA-DR+ cells was higher in both HIV and AIDS groups than in normal controls.The percentage of CD + 8 CD 38 + cells in AIDS groupin HIV groupnormal controls.There were positive correlations between percentages of CD + 8 CD 38 +,CD 8 HLA-DR +,CD + 4 HLA-DR + cells and plasma viral load.Conclusion In the process of HIV infection,expression of CD 38 HLA-DR on peripheral blood CD + 4 and CD + 8 T lymphocytes increased,reflecting the fact that T lymphocytes were abnormally activated,and that percentage of CD + 8 CD 38 + T cells increased along with disease progress,which can be used to predict the severity of the infection.In HIV infection monitoring,not only immunologic cells but also the level of cellular activation should be considered.
【Fund】: 北京市科学技术委员会资助 (合同编号 :H0 1 0 2 1 0 1 2 0 1 1 3)
【CateGory Index】: R512.91
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