Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal for China AIDS/STD》 2003-01
Add to Favorite Get Latest Update

Polymorphism of mannose-binding protein alleles associated with human immunodeficiency virus-1 infection in Chinese Han and Uigur ethnic populations.

SHI Hong,WANG Fu-sheng,WANG Zhe,et al.(Institute of Infectious Diseases No.302 Hospital of PLA,Beijing 100039,China)  
Objective To evaluate the polymorphism of mannose-binding protein(MBP)gene and its implication in human immunodeficiency virus-1(HIV-1)infection in individuals of Chinese Han and Uigur ethnic origins. Methods Genomic deoxyribonucleic acid(DNA)samples were purified from the whole peripheral blood of 856 subjects.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)assay was used for genotyping the exon 1 of mannose-binding protein genes,which was further confirmed by DNA sequencing by 310 genetic analyzer. Results Mutant frequencies of MBP-54 alleles were 0.189 and 0.121 for Han and Uigur healthy individuals respectively,showing significant differences between the two ethnic groups(χ 2=5.53,P=0.022).There is a good agreement with Hardy-Weiberg equilibrium for MBP-54 allelic distribution in these samples.The statistical analyses showed that there is no significant difference for allelic frequencies or genotypes among healthy individuals,high-risk populations and HIV-1 infected persons in Han and Uygur populations except for a statistical difference between HIV-1 infected persons and healthy controls in Uygur ethnic.In this study,no allelic mutations of either MBP-52 or MBP-57 genes were found in examined samples. Conclusion Our study suggests that genetic polymorphism of mannose-binding protein alleles are different between the Han and Uygur populations.Whether the higher mutant frequencies of MBP-54 allele in HIV-1-infected subjects are associated with the genetic susceptibility and disease progression is needed to be further clarified in follow-up investigation.
【Fund】: 国家自然科学基金资助项目 (39970 683);; 中国人民解放军“九五”医药卫生科研青年基金资助项目 (98Q1 0 3)
【CateGory Index】: R512.91
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Wang Fusheng, Feng Tiejian , Jin Lei, Wang Xiaohui, et al. Institute of Infectious Diseases, 302 Hospital, Beijing 100039, P. R . China;Polymorphisms of HIV - 1 Resistance Alleles in HIV - 1 Carriers in Shenzhen City of China[J];Journal for China AIDS/STD;2001-03
2 Chen Renbiao Ye Genyao Geng Zhencheng Wang Zenghui Kong FanhuaTian Ding Bao Piyun Liu Ruoying Liu Jie Song FangjiFan Lian Zhang Gongliang Guo ShishiXu Linmin Xu Xingpei Cheng DingzhenZhao Xiuzhu( Shanghai Institute of Immunology, Shanghai Second Medical University, WHO Collaborating Center lor Immunogenetics and Immunopathology; Beijing North Taiping Road Hospital; Genetics Institute, Fudan University; Neuroscience Institute, Guangzhou Medical College; Xuanwu Hospital, Capital Medical Col-left; Inner Mongolia Medical College; Guiyang Medical College; Haer-bin Red Cross Blood Center; No. 1 Affiliated Hospital, China Medical University; Shanghai Institute of Blood Transfusion; Hunan Medical University; Beijing Institute of Paediatrics; Wuhan Institute of Biological Produts; No. 1 Affiliated Hospital, Xinjiang Medical College; Sin-o-Australian Friendship Complement Laboratory, Tongji Medical university);Revelations of the Origin of Chinese Nation from Clustering Analysis and Frequency Distribution of HLA Polymorphism in Major Minority Nationalities in Mainland China[J];Acta Genetica Sinica;1993-05
3 WANG Fusheng 1, LIU Depei 2. 1(Department of Bioengineering, Beijing Institute of Infectious Diseases, Beijing, 100039 P. R. China. E mail: fushengw@public.bta.net.cn); 2(National Key Laboratory of Molecular Biology, Institute of Basic Medicine,;Polymorphism of human alleles associated with genetic resistance against HIV-1 infection and its implications[J];CHINESE JOURNAL OF MEDICAL GENETICS;2000-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Changying,HU Bin,WANG Tongxian,et al.Qingdao Blood Center,Qingdao 266071,China;The distribution of killer immunoglobulin-like receptor genes in Qingdao Han population[J];Chinese Journal of Blood Transfusion;2008-07
2 Chen Gang, Xue Hong, Zhou Yanjie et alChengdu University of Traditional Chinese Medcine (Chengdu,610075,China);Research of Bone-length Measurement in Miraculous Pivot —Camparison Study of Ancient and Modern Data of Measuring Body Surface[J];JOURNAL OF CHENGDU UNVERSITY OF TARDITIONAL CHINESE MEDICINE;1998-02
3 MAO Wei,HUANG Xia,WANG Rong-gan,et al.(Chongqing Blood Center,Chongqing 400015,China);Study on genetic polymorphism of HLA-A,B,DRB1 allele in Chongqing population[J];Chongqing Medicine;2006-14
4 Zhang Xiongying,Qin Xiongwei Department of Microbiology,Changzhi Medical College;Study on the Association Between HLA-DPB1 and Rheumatoid Atrhritis of the Han Nationality in Shanxi[J];Journal of Changzhi Medical College;2008-01
5 NIU Xiao-lin,WANG Ya-ping, ZHANG Hong-bo ,et al (Department of Cardiology,Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China);The study of genotyping of HLA-DRB1 by PCR-SSOP in Keshan disease in Shaanxi Province[J];Chinese Journal of Control of Endemic Disease;2003-06
6 Zhuo Xiaofu 1, Guo Yongjian 1, Yin Xuenian 2, et al (1.Faculty of Laboratory Medicine,Fujian Medical University,Fuzhou,350004 2.Department of Immunology,Jilin Medical College,132001);The Origin of She Ethnic Group[J];JOURNAL OF FUJIAN MEDICAL UNIVERSITY;1998-02
7 Bao Rong, Fang Jianpei, Huang Shaoliang, et al. Lingnan Cord Blood Bank, Sun Yat sen Memorial Hospital, Sun Yat sen University of Medical Sciences, Guangzhou 510120;Analysis and significance of HLA polymorphism in 106 Guangdong individuals of Han nationality[J];Guangdong Medical Journal;2001-08
8 Ma Hongjing, Xiao Lulu, Guo Kunyuan, et al. Department of Hematology, Zhujiang Hospital, Nanfang Medical University, Guangzhou 510282;Analysis of HLA-A, B, DRB1 allele frequencies in Guangdong Han population[J];Guangdong Medical Journal;2005-03
9 CHEN Sen-zhou,CHEN Zhe,FAN Xiao-hui,et al.Guilin Medical College,Guilin 541004,China;A study on the Gene-Polymorphism CCR5 of HIV carriers in Mulao Nationality of Luocheng County,Guangxi Zhuang Autonomous Region[J];Acta Medicinae Sinica;2007-06
10 HONG Kun-xue, CHU Jia-you , LI Dong-na, YU Jian-kun , XU Shao-bin , SHI Lei , LIN Ke-qin, TAO Yu-fen . (Department of Genetics, Institute of Medical Biology, Peking Union Medical College, Kunming 650118; Chinese Center for Disease Control and Prevention, Beijing 100050;Hainan Medical College, Haikou 571101 , P. R. China);Genetic Diversity of HLA-DRB1 ,DQA1 ,DQB1 in Chinese Li Population in Hainan[J];International Journal of Genetics;2006-05
China Proceedings of conference Full-text Database 1 Hits
1 Xie Xiao-dong Wang Xi-long Zhou Rui-xia Ma Ke-jun;A new vision of Hui Ethnological Evolution Analysis—Application of Molecular Genetic and Bioinformatics in the Study of Hui Origin[A];[C];2006
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Zhang Zhenbiao (Institute of Vertebrate Paleontology and Paleoanthropology, Academia Sinica);THE PHYSICAL CHARACTERS OF ZANG (TIBETAN) NATIONALITY[J];Acta Anthropologica Sinica;1985-03
2 Lin Shenglong (Institute of Vertebrate Paleontology and Paleoanthropology, Academia Sinica);TRENDS OF DISTRIBUTION OF EARLY MAN IN CHINA[J];Acta Anthropologica Sinica;1987-03
3 Wu Rukang (Institute of Vertebrate Paleontology and Paleoanthropology, Academia Sinica);A REVISION OF THE CLASSIFICATION OF THE LUFENG GREAT APES[J];Acta Anthropologica Sinica;1987-04
4 Zhao Tongmao Zhang Gongliang Zhu Yongming Zheng Suqin Gu Wenjuan(Shanghai Institute of Blood Transfusion 200003)Chen Qi Zhang Xia Liu Dingyuan(Fudan University, Shanghai);Study on Immunoglobulin Allotypes in the Chinese: A Hypothesis of the Origion of the Chinese Nation[J];Acta Genetica Sinica;1991-02
5 WANG Fusheng, JIN Lei, LEI Zhouyun, et al. 302nd Hospital of PLA, Beijing 100039,China;Distribution of HIV resistance CCR5-delta32, CCR2-64I and SDF1-3'A alleles and their polymorphisms in the Han population in China[J];CHINESE JOURNAL OF EPIDEMIOLOGY;2000-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved