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《Chinese Journal of AIDS & STD》 2010-02
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HIV-1 drug resistance mutations

LI Jing-yun.(PLA HIV Test Center,Institute of Microbiology & Epidemiology,Academy of Military Medical Science,Beijing 100071, China)  
The emergence of drug resistance has become a major obstacle to successful antiretroviral therapy,With the development of antiretroviral therapy and the application of novel antiretroviral agents,more than 200 drug resistance related mutations have been identified,and the influences of these mutations on drug sensitivity and biological characteristics of HIV have been analyzed. This paper reviews HIV -1 drug resistance mutations and their impacts on replication fitness and discusses the focus of future research on drug resistance
【Fund】: 国家自然科学基金重点项目(30830088)~~
【CateGory Index】: R512.91
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