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《Chinese Journal of AIDS & STD》 2010-05
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Analysis of polymorphism of RANTES and SDF1-3'A genes related to HIV-1 infected population and high-risk population in a group of Urghur ethnic in Xinjiang

ZHANG Jing-yu,ZHAO Rong-li,GUO Shu-xia,et al.(Department of Preventive Medicine,Medical College of Shihezi University,Shihezi city,Xinjiang 832002,China)  
Objective To analyze the frequency and polymorphism of the allele of RANTES and SDF1-3'A genes related to 275 high-risk cases and 275 HIV-1 infected cases among Urghur ethnic in Xinjiang.Method The allele of RANTES and SDF1-3′A genes from 275 blood samples in high-risk cases and infected cases were detected respectively by using PCR-RFLP method.Results In 275 high-risk cases,the mutation rate of allele of RANTES and SDF1-3′A genes were 14.2% and 19.7% respectively,and 19.6% and 24.7% of mutation rate were obtained in 275 infected cases(P0.05).Conclusion The mutation and frequency of the allele of RANTES and SDF1-3′A genes show no difference between HIV-1 infected population and high-risk population.
【Fund】: 新疆生产建设兵团医药专项(05GG36);; 国家自然科学基金(30700687)~~
【CateGory Index】: R512.91
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