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Synthesis of hepatic targeting antineoplatic agent NGA-DHAQ

Chen Wen; Li Tongling; Pang Qijie and Guan Changtian(Shihezi Medical College, Shihezi, 832002)  
Neoglycoalbumin(NGA), a special ligand of asialog;ycoprotein receptor on the hepatocyte,was Iinked via a butanediacyl bridge to mit0xantron to form a c0njugate NGA-DHAQ. The UV and HPLCanalysis showed that DHAQ was connected with NGA by covalent b0nds 8nd stable in blood.
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