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Study on the quality standard of Zanggubao Capsules

ZHOU Hong;GAO Suli;YANG Zhifu;WEN Aidong;Department of Pharmacy,the First Affiliated Hospital of the Fourth Military Medical University of PLA;  
Objective To establish a quality standard for Zanggubao Capsules.Methods TLC was adopted to identify alantolactone and oleanic acid in the preparation;HPLC was adopted to determine the content of aesculin and esculetin in the preparation;the column was Kromasil C18(150 mm×4.6 mm,5μm)with mobil phase of acetonitrile-1 mL·L~(-1) phosphoric acid solution(12∶88)at a flow rate of 1.0 mL·min-1,the detection wavelength was 334 nm,column temperature was 25 ℃,the injection volume was 20μL.Results TLC showed clear spots and good separation.The linear range of aesculin concentration was 5.42-54.2μg·mL~(-1)(r=0.999 3),the linear range of esculetin concentration was 3.28-32.8μg·mL~(-1)(r=0.999 5);recovery of aesculin was 100.06%(RSD=1.14%,n=9),and recovery of esculetin was 100.80%(RSD=1.68%,n=9).Conclusion The method was convenient,rapid and accurate,and can be used for the quality control of Zanggubao Capsules.
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