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Protective effects of Isosorbide-5-Mononitrate Sustained Release Tablets on the testis of chronic mountain sickness rat model

WANG Lei;CHEN Shizhan;Maierhaba TURSUN;LI Lidan;LIU Junfu;XIE Mengjun;Anwar HEKIM;College of Pharmacy,Xinjiang Medical University;College of Houbo,Xinjiang Medical University;College of Traditional Chinese Medicine,Xinjiang Medical University;Central Laboratory,Xinjiang Medical University;  
Objective To study the role of Isosorbide-5-Mononitrate Sustained Release Tablets on the protection effect in the testis of the chronic mountain sickness rat model.Methods Rats were randomly divided into blank control group,high altitude group,nifedipine group,and low,medium,high dosage Isosorbide-5-Mononitrate Sustained Release Tablets group.The changes of pulmonary artery pressure(PAP)and the testis tissue were observed.The test was conducted in these rats to check their interleukin-6(IL-6),C-reactive protein(CRP),superoxide dismutase(SOD),malondialdehyde(MDA)and glutathione peroxidase(GSH-PX).Results Compared with the blank control group,the PAP,IL-6,CRP and MDA levels of high altitude group,nifedipine group,high,medium,low dosage Isosorbide-5-Mononitrate Sustained Release Tablets group were higher,but SOD and GSH-PX levels were lower.Optical microscopy showed that testis tissue was injured,which indicated the testis of the rat was damaged under hypoxic conditions.Compared with the high altitude group,the PAP,IL-6,CRP and MDA levels of high altitude group,nifedipine group,and high,medium,low dosage Isosorbide-5-Mononitrate Sustained Release Tablets group were lower,but the SOD and GSH-PX levels were higher.Each index was closed to the normal result and better than the positive control group index.The testis tissue pathology also appeared satisfactory results.Conclusion High dosage Isosorbide-5-Mononitrate Sustained Release Tablets has protection effect in the testis of the chronic mountain sickness rat model.
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