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Preparation of acyclovir microemulsion and examination of its physical chemical properties

YIN Xudong;CHENG Wei;KONG Yunhong;YANG Xiaohong;Department of Life Science and Technology,Kunming University;  
Objective To establish a stable acyclovir microemulsion formulation.Methods The blank microemulsion was prepared by complex surfactant sodium oleate,castor oil polyoxyethylene ether EL-60 and Tween-80 in aqueous solution with oleic acid as oil phase.Acyclovir microemulsion was prepared by adding adjuvant glycerol to blank microemulsion.The physical and chemical properties such as the form,the diameter and the potential of the acyclovir microemulsion were detected by transmission electron microscope(TEM)and laser scattering method.Results Acyclovir microemulsion particles showed an average particle diameter of 40.28 nm and a pH of 6.82 with a small particle size range.Conclusion Acyclovir microemulsion formulation is relatively stable,close to neutral.It is wealth of study further.
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