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Study of salvianolic sorbefacient and its preparation of dropping pills

ZHAO Fengzhi;CHEN Sisi;LIU Ligen;SHI Xinhong;Department of Traditional Chinese Medicine Preparations,China Pharmaceutical University;  
Objective To select a proper sorbefacient concentration for salvianolic dropping pills and to optimize its formulation and process parameters.Methods The in vivo uni-directional intestinal perfusion was used to inspect the transdermal effect of sodium caprate on salvianolic.The single factors and orthogonal experiment were used to filter the prescription and process.Results The promote density of sodium caprate was 4.76%,and the optimal conditions were PEG6 000∶PEG4 000=1∶4,drug matrix ratio of1∶3 and with water 10%,coolant of dimethicone H201-500 cs,material droplet system temperature 80℃,dripping distance 4 cm,and dropper inner diameter 2.5 mm.Conclusion The prepared salvianolic dropping pills showed high roundness,fast disintegration,and higher bioavailability.The process is simple,easy to repeat,and suitable for industrial production.
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