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Analgesic and anti-inflammatory effects ofZhitongling (ethenzamide )

Shan Zhong, Jia Min, Fang Kun-quan, Zhao De-hua(Dept. of Pharmacology, The fourth Military Medical University, Xi'an 710032)  
Taken in Zhitongling (268. 5 or 537. 1mg/kg), that can inhibit themouse reaction of glacial acetic acid significantly, and can raise its pain threshold of thehot-plate way (P0.05 or P0.01). Taken in the drug(134.4) 268. 5 and 537. 1mg/kgrespectively), those all can inhibit the swelling level of mouse auricle caused by croton oil(P0.05 or P0.01). 268. 5 and 537. 1mg/kg, so do in the eggwhite-like swelling level of the rat feet (P0.05 or P0.01); 537. 3mg/kg also inhibits the formation of ratgranulation. LD50 of Zhitongling in is 2. 69g/kg to the mouse. LD50 of Aspirin is 1.36g/kg. The results indicate: Zhitongling has stronger analgesic and anti-inflammatory effects; and the toxicity is lower than Aspirin.
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