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《Acupuncture Research》 2008-01
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Effect of Acupotomy Lysis on SP and CCK-8 Contents in Hypothalamus and Spinal Cord in Rats with Transverse Process Syndrome of the Third Lumbar Vertebra

HU Bo,LIU Lin,GUO Chang-qing,LI Xiao-hong,SUN Hong-mei,LIU Nai-gang,LU Jing,GU Shi-zhe,MA Hui-fang (College of Acu-moxibustion,Beijing University of Chinese Medicine,Beijing 100029,China)  
Objective To observe changes of SP and CCK-8 contents in the hypothalamus and spinal cord after performing acupotomy lysis so as to study its central analgesic effect in rats with transverse-process syndrome of the third lumbar vertebra.Methods Twenty-eight SD rats were randomly divided into normal control group,model group,acupotomy lysis group and electroacupuncture(EA) group,with 7 cases in each one.The model of the third lumbar vertebra transverse process syndrome was established by inserting a piece of gelatin sponge into the deep subfascial part of the 3rd lumbar transverse process.Acupotomy lysis was conducted 1 time/week for 2 weeks.EA(2/100 Hz,1-2 mA) was applied to the left "Shenshu"(BL 23)-"Yaoyangguan"(GV 3) for 20 min/time,3 times/week and for 2 weeks.SP and CCK-8 contents in the hypothalamus and spinal cord were detected with enzyme linked immunosorbent assay(ELISA).Results In model group,SP and CCK-8 contents in the hypothalamus and spinal cord were increased significantly in comparison with normal control group(P0.01).Compared with model group,both SP and CCK-8 contents in hypothalamus and SP content in spinal cord in acupotomy lysis and EA groups were apparently lower(P0.01,0.05).CCK-8 content in spinal cord in cupotomy lysis group was lower markedly than that of model group(P0.01),while no significant difference was found between model group and EA group in CCK-8 level in spinal cord(P0.05).Conclusion Acupotomy lysis can downregulate SP and CCK-8 contents in hypothalamus and spinal cord,which may contribute to its effect in relieving pain from transverse process syndrome of the third lumbar vertebra.
【Fund】: 国家重点基础研究发展计划“973”项目(2005CB523307)
【CateGory Index】: R245.319
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