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《Acupuncture Research》 2017-06
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Effects of Acupuncture at“Shenmen”(HT 7) on Brainwaves and Cognitive Ability in Rats with Sleep Deprivation

LI Jia;LIU Jiao-ping;Hubei University of Chinese Medicine/Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion;Department of Oncology,Integrated Chinese and Western Medicines,Wuhan Central Hospital,Tongji Medical College,Huazhong University of Science & Technology;  
Objective To observe the effects of acupuncture at"Shenmen"(HT 7)on brainwaves and cognitive ability in rats with sleep deprivation.Methods SD rats were randomly divided into control group,model group,acupuncture group and sham acupuncture group,15 rats in each group.Insomnia model rats were established by sleep deprivation for 72 hours.Acupuncture was applied to acupuncture group at bilateral"Shenmen"(HT 7)for 20 min,once daily for 7 days.Rats in the sham acupuncture group received superficial insertion of 1 mm and without retaining needle.The learning and memory abilities of rats were evaluated by Hexagonal maze.The BL-420 Fphysiological recorder was used to record EEG for 30 min on the 1 st,4 th,7 th and 10 th day respectively,and the frequency of each wave was analyzed.Results After sleep deprivation,the frequency of searching the exits of Hexagonal maze in the model group was obviously increased,the searching time was shortened,the number of searching errors was increased obviously,and the cognitive rate was decreased(P0.01).Compared with the model group and the sham acupuncture group,the frequency of searching the exits in the acupuncture group was obviously decreased,the searching time was longer,the number of seeking errors was decreased,and the cognitive rate was increased(P0.05).Compared with the control group,the EEG ofδwave in the model group was decreased whileβwave increased with statistical significance(P0.01).Compared with the model group,theδwave of rats in the acupuncture group was significantly increased and theβwave was significantly decreased(P0.05).There were no statistically significant differences between the sham acupuncture group and the model group(P0.05).Conclusion Acupuncture at HT 7 can effectively improve the cognitive abilities and brainwaves in sleep deprived rats.
【Fund】: 国家自然科学基金(No.81403460);; 湖北中医药大学校级课题(No.2013-144 XJ 2014KJ 003)
【CateGory Index】: R245
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