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《Modern Chemical Industry》 2001-08
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Chiral separation of naproxen on molecular imprinted polymers

LEI Jian du, TAN Tian wei (Department of Biochemical Engineering,Beijing University of Chemical Technology,Beijing 100029, China)  
In the presence of template molecule of naproxen,molecular imprinting polymer of naproxen was prepared by using of acrylamide as functional monomer and ethylene glycol dimethacrylate as crosslinking agent,and evaluation by means of high efficient liquid chromatograph was carried out.The result showed that the racemic naproxen was efficiently resolved,and the ibuprofen and ketoprofen similar to naproxen in structure were separated from naproxen.The mechanism of chiral recognition was discussed.Effects of flow rate and concentration of acetic acid in the mobile phase on separation were studied.
【Fund】: 国家自然科学基金资助 (No .2 99760 0 4 )
【CateGory Index】: TQ460
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Chinese Journal Full-text Database 3 Hits
1 JIAO Feipeng HUANG Kelong YU Jingang PENG Xiahui ZHAO Xuehui NING Fengrong (College of Chemistry and Chemical Engineering,Central South University,Changsha 410083);Study on Process of Thermodynamics for Chiral Separation of Naproxen in Molecular Imprinting[J];Materials Review;2005-08
2 Feng Xiwen1,Du Ping2,Zhang Li2(1.School of Material and Chemical Engineering,Sichuan University of Science & Engineering,Zigong 643000;2.School of Chemistry and Pharmaceutical Engineering,Sichuan University of Science & Engineering,Zigong 643000,China);The Application of Molecular Imprinting Technologies on Active Ingredients Extraction and Purifica tion from Natural Drug[J];Guangdong Chemical Industry;2011-02
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1 LU Cheng-yu,LI Hong,SUN Xue-feng,YANG Shi-jie (Department of Pharmacology,School of Basic Medical Sciences, Jilin Universitym,Changchun 130021 China) [;Antihypertensive effect of L-amlodipine in SHRs and anaesthetic dogs[J];;2001-02
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3 YANG Shui-jin~1 LIANG Yong-guang~1 YU Xin-wu~1 SUN Ju-tang~2 [WT4”BZ](1.Department of Chemistry,Hubei Normal University, Huangshi 435002,China 2.Department of Chemistry,Wuhan University, Wuhan 430072,China);Catalytic Synthesis Nipagin Esters with TiSiW_12O_40/TiO_2[J];China Surfactant Detergent & Cosmetics;2000-04
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【Secondary References】
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1 ZHU Qiu-jin1,DAI Jun2,CHENShang-wei2,GU Xiao-hong2,TANG Jian2(1.School of Life Science,Guizhou University,Guiyang550025;2.Testing &Analysis Center,Southern Yangtze U-niversity,Wuxi 214036,Jiangsu);THERMODYNAMICS STUDY OF SEVERAL STEROLS ISOMERS SEPARATION ON TFMAA-co-TIRM MOLECULARLY IMPRINTED POLYMER[J];Guizhou Science;2007-S1
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